Study of Genetic Polymorphisms in Thai HIV-1 Infected Patients on SQV/r

Study of Genetic Polymorphisms of CYP 3A and MDR-1 Genes in Thai HIV-1 Infected Patients on Saquinavir/Ritonavir

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00476502

Enrollment

250

Registered

2007-05-22

Start date

2006-02-28

Completion date

2008-12-31

Last updated

2012-04-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV Infections

Keywords

genetic polymorphism, CYP 3A, MDR-1, Thai, HIV, Treatment Experienced

Brief summary

Study of genetic polymorphisms of CYP #A and MDR-1 genes in Thai HIV-1 infected patients on saquinavir/ritonavir.

Detailed description

Genetic polymorphisms will be investigated by polymerase-chain reaction (PCR) and drug levels of saquinavir will be determined by high phase liquid chromatography with UV-detected (HPLC).

Interventions

GENETICidentify genetic polymorphism in Thai HIV infected

Gene sequencing of Cyp450 metabolic pathway

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* HIV-infected persons who have been enrolled in the Staccato study * On low-dose ritonavir boosted saquinavir at the time blood samples are collected

Exclusion criteria

* Inability to understand the nature and extent of the study and the procedures required

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026