Glucocorticoid Metabolism, Hyperandrogenism
Conditions
Keywords
androgens, fatty acids
Brief summary
The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
Detailed description
Free fatty acids (FFA) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. In addition, FFAs seems to have a stimulatory effect on adrenal androgen precursors in men. However, the effect of FFAs on androgen precursors and androgens in women is yet unknown. Therefore the effect of increased FFAs on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.
Interventions
DRUGlipid/heparin infusion
to perform an i.v. lipid heparin infusion infusion for 4 h
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy men and women
Exclusion criteria
* diabetes mellitus or impaired glucose tolerance * clinical signs of hyperandrogenism * polycystic ovary * hormonal therapy * BMI \> 30 kg/m2 * dysmenorrhoea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of androstenedione | 1 day | Measurement of serum androstenedione |
| change of DHEA | 1 day | Measurement of serum DHEA |
| change of DHEAS | 1 day | Measurement of serum DHEAS |
| change of testosterone | 1 day | Measurement of serum testosterone |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| urinary androgen excretion | 1 day | — |
| urinary cortisol excretion | 1 day | measurement of urinary cortisol, aTHF and THF |
| urinary cortisone excretion | 1 day | measurement of urinary cortisone and THE |
| changes in metabolic parameters (e.g. FGF-21) | 1 day | — |
Countries
Germany
Outcome results
None listed