Six Months DHEA Treatment in Female Adrenal Failure

Physiolocal Effects of 6 Months DHEA Substitutional Therapy in Female Adrenal Failure in a Randomised, Placebo Controlled and Overcrossed Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00471900

Enrollment

Registered

2007-05-10

Start date

2001-10-31

Completion date

2003-02-28

Last updated

2007-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenal Insufficiency

Brief summary

DHEA is an adrenal deriven androgen precourser. The impact of DHEA substitution therapy in adrenal failure is unknown as well as the physiologically effects of DHEA is unknown. Effects of physiologically DHEA substitution is investigated in the model of female adrenal failure.

Interventions

DRUGdehydroepiandrosterone (DHEA)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Female, * Adrenal insuficiency, * Stable and safe anticonception, * Stable hydrocortison substituation treatment.

Exclusion criteria

* Neoplastic and thromboembolic disease, * Diabetes mellitus.

Design outcomes

Primary

Measure	Time frame
Quality of life parameteres, cardiovascular parameters, bodycomposition, exercise parameters, hormonal and serological parameters, fuel metabolisme.	six months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026