Menopause, Ovarian Failure, Premature, Perimenopause, Sex Chromosome Aberrations, Turner Syndrome
Conditions
Keywords
Ocular Surface Disease, Imprinting, Eye Abnormalities, Ovarian Insufficiency, Women's Eye Health and Disease, Turner Syndrome, TS, Premature Ovarian Failure, POF, Healthy Volunteer, HV
Brief summary
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.
Detailed description
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition. From preliminary data, we suspect that women with Turners syndrome (45, XO), a genetic abnormality that affects sex hormone levels, are also at increased risk of ocular surface disease. Comparing POF and TS women may allow us to distinguish different mechanisms for ocular surface disease, due to the different etiologies of hormonal (estrogen and androgen) alterations posed by POF and TS.
Interventions
None listed
Sponsors
National Eye Institute (NEI)
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* INCLUSION CRITERIA: 1. Ability to understand and give informed consent. 2. Meet the diagnostic criteria for TS (45, X0) or premature ovarian failure OR age matched control for study participant with TS or POF. 3. For non Turner syndrome subjects only - Negative pregnancy test or post menopausal status for greater than or equal to 1 year. 4. Karyotype of XO for TS subjects or XX for POF and age matched control subjects.
Exclusion criteria
1. Persons less than 18 years old. 2. Persons with ophthalmic diseases associated with ocular surface disease. 3. Hyperprolactinemia. 4. Cushing s syndrome. 5. Other endocrine disorders which impact sex steroid hormones. 6. AIDS 7. Pregnancy or lactation. 8. For age matched control population ONLY- complaints of dry eye. 9. For age matched control population ONLY- oral contraceptives or menopausal hormone therapy or any medications which alter sex hormone levels in the blood or chronic usage of medications that induce dry eye.
Countries
United States
Outcome results
None listed