Fetomaternal Transfusion
Conditions
Keywords
Feto-maternal transfusion, Kleihauer-Betke
Brief summary
Study hypothesis: umbilical cord drainage of fetal blood after delivery of the infant would reduce the incidence of feto-maternal transfusion. Patients were randomized to placental drainage or no drainage at the time of cesarean section. The incidence of fetal to maternal transfusion was noted postoperatively.
Detailed description
86 patients were randomized to placental drainage vs. no drainage of fetal blood at the time of cesarean section. Kleihauer-Betke testing was performed within 12 hours postoperatively to assess the incidence of feto-maternal transfusion. A significant difference was found between the two groups.
Interventions
PROCEDUREdrainage of placenta of fetal blood
Sponsors
Lester E. Cox Medical Centers
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* All women undergoing cesarean section
Exclusion criteria
* Preoperative Kleihauer-Betke, known antepartum erythrocyte sensitization, overt vaginal bleeding, history of a previous delivery by low vertical cesarean section, prolonged rupture of membranes, twin gestation, failure to obtain both preoperative and postoperative Kleihauer-Betke tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence/absence of fetal blood in maternal circulation | within 12 hours postoperatively |
Secondary
| Measure | Time frame |
|---|---|
| no secondary outcome measures | end of study |
Outcome results
None listed