Coronary Artery Disease
Conditions
Keywords
PCI, stent, training, endothelial function, restenosis, late luminal loss, heart rate variability, oxygen uptake capacity, inflammatory markers
Brief summary
The Efector study is an open, randomized and controlled trial assessing the effect of regular exercise training on endothelial function, inflammatory markers, progression of disease, heart rate variability and mental health in patients who have been successfully treated with percutaneous coronary intervention and stent implantation for angina pectoris.
Detailed description
Pas er randomized to a 6 months training group or none training. At baseline and at 6 months patients are examined with blood tests to measure serum concentrations of inflammatory markers, a test for endothelial function, heart rate variability and a coronary angiogram. Further patients are asked to answer questionnaires concerning mental health (SF36, HADS).
Interventions
BEHAVIORALexercise training
Exercise training in groups
Sponsors
Helse Stavanger HF
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Successful PCI with stent implantation, * Able to participate in the training program, * No planned further revascularisation
Exclusion criteria
* CAGB, * Inflammatory diseases other than CAD, * Heart failure, * Severe kidney failure, * Inability to participate in the training program
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| flow mediated dilation, serum concentrations of biomarkers, restenosis-rate/ late luminal loss, heart rate variability in SDNN | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Oxygen uptake capacity (mg/kg/min), Sf36 scores | 6 months |
Countries
Norway
Outcome results
None listed