Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock

Conditions

Cardiogenic Shock, Myocardial Infarction

Keywords

Myocardial infarction, Cardiogenic shock, Systemic inflammatory response syndrome, Percutaneous coronary intervention, aortic balloon counterpulsation

Brief summary

The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.

Detailed description

Patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) with cardiogenic shock (CS) are often treated with Intra-aortic balloon pump counterpulsation (IABP) although the evidence to support this is limited. We conducted a prospective, randomised clinical trial, of IABP as an addition to PCI centred therapy, in patients with AMI complicated by CS. 45 patients with AMI and CS undergoing PCI were randomised to care with or without IABP. Over 4 days, APACHE II scores, haemodynamic parameters, inflammatory markers and BNP levels were collected to assess the impact of IABP treatment on CS triggered multi organ dysfunction syndrome (MODS).

Prondzinsky R, Unverzagt S, Lemm H, Wegener N, Heinroth K, Buerke U, Fiedler M, Thiery J, Haerting J, Werdan K, Buerke M.

2012-07-2038 citations

10.1007/s00063-012-0117-y

Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP shock trial.

Prondzinsky R, Unverzagt S, Russ M, Lemm H, Swyter M, Wegener N, Buerke U, Raaz U, Ebelt H, Schlitt A, Heinroth K, Haerting J, Werdan K, Buerke M.

2012-04-01108 citations

10.1097/shk.0b013e31824a67af

Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock.

Prondzinsky R, Unverzagt S, Lemm H, Wegener NA, Schlitt A, Heinroth KM, Dietz S, Buerke U, Kellner P, Loppnow H, Fiedler MG, Thiery J, Werdan K, Buerke M.

2012-01-0395 citations

10.1007/s00392-011-0403-3

Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome.

Prondzinsky R, Lemm H, Swyter M, Wegener N, Unverzagt S, Carter JM, Russ M, Schlitt A, Buerke U, Christoph A, Schmidt H, Winkler M, Thiery J, Werdan K, Buerke M.

2010-01-01232 citations

10.1097/ccm.0b013e3181b78671

Interventions

DEVICEIntra-aortic balloon pump counterpulsation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

No

Inclusion criteria

* Acute myocardial infarction * Cardiogenic shock

Exclusion criteria

* Absent peripheral pulses * Mechanical complications of myocardial infarction

Design outcomes

Primary

Measure	Time frame
APACHE II SCORE	4 days

Secondary

Measure	Time frame
Haemodynamic state	4 days
BNP levels	4 days
Inflammatory activation	4 days
Mortality	4 days

Countries

Germany

Outcome results

None listed