Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00468663

Enrollment

4200

Registered

2007-05-03

Start date

2006-07-31

Completion date

2009-05-31

Last updated

2015-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia, Preterm Delivery

Keywords

preeclampsia, preterm delivery, lipid peroxidation, inflammation

Brief summary

An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.

Detailed description

We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy. We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Age

18 Years to No maximum

Inclusion criteria

* English speaking * enrolled in parent study * pregnant at \<20 weeks gestation and attending prenatal care clinics affiliated with Swedish Medical Center and Tacoma General Hospital

Exclusion criteria

Outcome results