Trauma
Conditions
Keywords
CCK release
Brief summary
Patients undergoing major surgery, trauma and burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently our group demonstrated that administration of high fat feeding prior to hemorrhagic shock attenuates severe inflammation, gut barrier loss and hepatic damage. High fat feeding releases cholecystokinin in the gut, which stimulates the autonomous nervous system and subsequently activates the efferent vagus nerve. The activated efferent fibers inhibit tissue macrophages via binding of acetylcholine to the alpha7-nicotinergic receptor. In this study the cholecystokinin release in healthy volunteers is monitored in response to low fat and high fat food products.
Interventions
DIETARY_SUPPLEMENTnutritional intervention with Respifor and Diasip
Four nutritional interventions on four separate days per test person
Sponsors
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
45 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy males and females * 45 \> age \<55
Exclusion criteria
* Gastrointestinal diseases * Inflammatory conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CCK-release | two hours |
Countries
Netherlands
Outcome results
None listed