Holotranscobalamin Remains Unchanged During Pregnancy

Holotranscobalamin Remains Unchanged During Pregnancy. Longitudinal Changes of Cobalamins and Its Binding Proteins During Pregnancy and Postpartum

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00467623

Enrollment

150

Registered

2007-04-30

Start date

1995-01-31

Completion date

1997-12-31

Last updated

2008-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin B12 Deficiency

Keywords

Pregnancy, holotranscobalamin, cobalamin, vitamin B12 analogues, reference interval

Brief summary

Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins, transcobalamin (total TC, holoTC) and haptocorrin (total HC, holoHC). TC transports cobalamin into the cells. The function of HC is unknown, but in contrast to TC it binds both cobalamins and cobalamin analogues. Design and methods: Healthy pregnant women (N=141) had blood samples drawn at 18th, 32nd, 39th gestation week and 8 weeks postpartum. The protein moiety of TC and HC (total and holo) was measured by in-house ELISA methods.

Detailed description

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Danish healthy Caucasian women \>18 years of age with previous uncomplicated pregnancies and deliveries and presently with a normal pregnancy.

Exclusion criteria

* \>4 cigarettes smoked per day, * Treatment with vitamin B12, folic acid or acetyl salicylic acid, * Impaired renal function and clinically significant vaginal haemorrhage before first visit as well as blood haemoglobin \<6.4 mmol/L at first visit.

Countries

Denmark

Outcome results