Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour Application

Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00466570

Enrollment

Registered

2007-04-27

Start date

2007-04-30

Completion date

Unknown

Last updated

2013-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Conjunctical Flora

Brief summary

Topical ophthalmic antibiotics are common prescribed just prior to eye surgery to lower the risk of infection. Previous studies have suggested that antibiotics containing a preservative (Zymar) kill bacteria much quicker than those without a preservative (Vigamox). The purpose of this research is to compare how quickly to the two commonly prescribed antibiotics eliminate bacteria from the eye surface.

Interventions

DRUGgatifloxacin, moxifloxacin

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

PREVENTION

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age- older than 50 years of age * Diagnosis- Cataract or had cataract surgery

Exclusion criteria

* Systemic or topical antibiotic treatment within 30 days * Use of systemic or topical steroids * Active ocular infection * Ocular surgery in the past 6 months * Allergy to fluoroquinolones

Design outcomes

Primary

Measure	Time frame
Antibiotic killing of conjunctival bacterial flora 1 hour after application	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026