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Improved Management and in-Hospital Mortality

Reduced in-Hospital Mortality After Improved Management of Patients Hospitalised With Malaria. A Randomised Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00465777
Acronym
MTV
Enrollment
950
Registered
2007-04-25
Start date
2004-12-31
Completion date
2006-02-28
Last updated
2007-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria, Mortality

Keywords

malaria, mortality, hospital, incentive, personnel, paediatric

Brief summary

The study intend to evaluate whether the use of standardised malaria case management protocol plus financial incentives added to the availability of free drugs reduce the case-fatality at the paediatric ward.

Detailed description

Mortality at the national paediatric ward in Guinea-Bissau is very high. During a civil war in 1998/1999 the hospital case fatality (CF) decreased by more than 40%, increasing again after the the war. This was attributed to the available free drugs from the humanitarian aid and food incentives to the personnel. Free emergency kits for treatment of severe malaria was introduced, however the CF did not decline. Therefore, the ward was split into two groups of rooms: intervention and control. All the staff of the ward was trained in the use of a standardised guideline for treatment of severe malaria and randomly assigned to one of the groups. All children hospitalised for malaria received the drug emergency kits. The only difference in the intervention group were the small financial incentives and supervision for strict adherence to the guidelines procedures.

Interventions

BEHAVIORALGuideline adherence and financial incentive

Sponsors

Statens Serum Institut
CollaboratorOTHER
World Health Organization
CollaboratorOTHER
Bandim Health Project
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
3 Months to 5 Years
Healthy volunteers
No

Inclusion criteria

* Hospitalization due to malaria * Non per os

Exclusion criteria

* Consent from parent/caretaker declined

Design outcomes

Primary

MeasureTime frame
In-hospital case-fatality

Secondary

MeasureTime frame
Cumulative post-discharge mortality on day 28 and length of hospitalisation

Countries

Guinea-Bissau

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 6, 2026