Eczema
Conditions
Keywords
Eczema, Pediatric, Vitamin B12
Brief summary
This study is being done to see in B12 applied to the skin will improve the symptoms of eczema in children compared to a placebo creme
Detailed description
INTRODUCTION: Atopic dermatitis is a prevalent disease process in children, affecting up to 20% of children in the United States. Various treatment options are available to treat atopic dermatitis to include topical emollients, topical steroids, and topical calcineurin inhibitors. Each treatment option has benefits and potential risks. This study was done to determine if topical B12 could be a tolerable and efficacious alternative treatment option in this population. METHODS: The study was conducted as a placebo-controlled, double-blind, prospective, randomized clinical trial with intraindividual left ⁄ right comparison. Parents were given 2 containers of creams and instructed to apply the Vitamin B12 cream to one side of the body and the placebo cream to the contralateral side according to the randomization scheme.
Interventions
DRUGTopical B12 0.07%
Sponsors
Spartanburg Regional Healthcare System
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
6 Months to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* children presenting to the Center for Family Medicine or Regional Pediatrics between the ages of 6 months and 18 years old with atopic dermatitis
Exclusion criteria
* unwillingness of parent to consent to study protocol, pregnancy or lactation, eczema with superinfection present, known history of allergy to Vitamin B12 or components of the base cream, topical treatment with corticosteroids in the 4 weeks prior to enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in SCORAD at 2 and 4 weeks | — |
Countries
United States
Contacts
Primary ContactRonald P Januchowski, D.O.
Backup ContactMary E Johnson
Outcome results
None listed