Osteoarthritis
Conditions
Keywords
Osteoarthritis, Cartilage, Exercise, Progressive Resistance Training
Brief summary
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months. It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA. Primary Outcome: Articular cartilage morphology following 6 months high intensity progressive resistance training Secondary Outcomes: Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post) Medications (pre, 3 months, & post) Body composition (pre, 3 months, & post) Balance; Physical function (pre, 3 months, & post) Questionnaires (pre, 3 months, & post) * Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability) * Depressive symptoms (Depression Scale) -Quality of life (SF36) * Confidence performing physical activity (Ewart) -Demographics
Interventions
BEHAVIORALProgressive resistance training
Sponsors
University of Sydney
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
FEMALE
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Female * Aged over 40 years old * Primary Osteoarthritis in at least one knee using standard criteria of the American College of Rheumatology (ACR) criteria for classification of clinical osteoarthritis * Ambulatory without human assistance * Willingness to be randomised to experiential or control group * Ability to attend scheduled exercise and testing sessions
Exclusion criteria
* Regular exercise of any kind over the past 3 months (\>1dpw). * Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemochromatosis, Wilson's disease and other rare forms of arthritis * Joint injury, injection or surgery within the past 6 months or knee joint replacement * Contraindications to MRI/Exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Articular cartilage morphology following 6 months high intensity progressive resistance training | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post) | — |
| Medications (pre, 3 months, & post) | — |
| Body composition (pre, 3 months, & post) | — |
| Balance; Physical function (pre, 3 months, & post) | — |
| Questionnaires (pre, 3 months, & post): | — |
| Muscle and fat cross-sectional area (CSA) (pre and post) | — |
| WOMAC index (pain, stiffness and functional ability) | — |
| Depressive symptoms (Depression Scale) | — |
| Quality of life (SF36) | — |
| Confidence performing physical activity (Ewart) | — |
| Demographics | — |
| Habitual exercise (PASE) | — |
Countries
Australia
Outcome results
None listed