Respiratory Distress Syndrome, Adult
Conditions
Keywords
ARDS, Pressure/time curve, Stress Index
Brief summary
30% of ARDS patients ventilated according to NIH protocol presents CT scan evidence of hyperinflation. Functional analysis of pressure-time curve (Stress Index=SI) has been shown to identify this condition in experimental settings. We tested the hypothesis that the SI is an accurate predictor of mechanical stress due to overdistention in ARDS patients.
Detailed description
The study presents two parts : a preliminary validation study and a clinical study.
Interventions
PROCEDUREChange ventilatory parameters with stress index monitoring
Sponsors
University of Turin, Italy
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Diagnosis of ARDS based on American-European Consensus Conference criteria
Exclusion criteria
* \>3 days since ARDS criteria were met and mechanical ventilation was started * History of ventricular fibrillation or tachyarrhythmia, unstable angina or myocardial infarction within preceding month * Pre-existing chronic obstructive pulmonary disease * Major chest wall abnormalities * Chest tube with persistent air leak * Abdominal distension * Body mass index \>30 * Pregnancy * Known intracranial abnormality * Enrollment in another interventional study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reduction of pulmonary inflammatory mediators | — |
Countries
Italy
Contacts
Primary ContactV. M. Ranieri, MD
Backup ContactP. Terragni, MD
Outcome results
None listed