Obesity
Conditions
Keywords
fat absorption, fibres
Brief summary
Randomized trial to test the effect of flaxseed fractions on appetite regulation and intestinal lipid absorption.
Detailed description
Randomized multiple crossover trial in 18 healthy males aged 18 to 40 years each are required to complete a total of five iso-caloric meal tests lasting approximately 8½ hours. Test meals will be given as breakfast meals, in which different fractions of flaxseeds are incorporated into baked products. Appetite will be registered using visual analogue scales during 7 hours after the test meal and a total of 10 blood samples will be drawn to evaluate TAG in chylomicrons, plasma LDL, HDL and total cholesterol, plasma TAG, insulin, glucose and appetite hormone levels. At the end of the test day an ad libitum meal will be served and food intake registered.
Interventions
DIETARY_SUPPLEMENTWhole flaxseeds, flaxseed mucilage, glucomannan
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy males aged 18-40 years * Normal weight or moderately overweigh (BMI 25-30 kg/m2)
Exclusion criteria
* Blood drawing/donation less than six months prior to start of the study * Hemoglobin concentration \<8mmol/L * Chronic diseases (i.e. diabetes, CVD), hypertension, hyperlipidemia * Consumption of dietary supplements including vitamin tablets * Smoking * Excess physical activity (\>10h of intense physical activity per week) * Medicine use (not including occasional consumption of pain killers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| appetite hormone levels | — |
| TAG in chylomicrons | — |
| serum TAG | — |
| HDL, LDL and total cholesterol | — |
| appetite scores | — |
| ad libium food intake | — |
Secondary
| Measure | Time frame |
|---|---|
| free fatty acid profile | — |
| plasma glucose | — |
| plasma insulin | — |
| meal macronutrient composition | — |
| meal energy content | — |
| meal pleasantness | — |
Countries
Denmark
Outcome results
None listed