Memory Deficit
Conditions
Keywords
Sleep apnea obstructive syndrome (SAOS), memory deficit, Continuous Positive Airway Pression (CPAP), Sham CPAP
Brief summary
The main objective of this study is to evaluate the evolution of memory deficit (verbal episodic memory, procedural memory, working memory, short-term memory) in Sleep Apnea Obstructive Syndrome (SAOS) patients after treatment by Continuous Positive Airway Pressure treatment (CPAP). For thus, we will compare memory tests in two separate groups of SAOS patients with effective versus ineffective ( or sham) CPAP, before and 6 weeks after the beginning of the treatment. Thus we will assess the evolution of memory deficit, the effectiveness of the treatment on the evolution of memory deficit before and 6 weeks after the beginning of the treatment by effective versus ineffective CPAP. We feel the results of the tests of memory will show greater memory disorders in patients with SAOS before beginning the treatment rather than six weeks afterwards. Thus we hypothesise that, after the treatment by effective CPAP, the patients with SAOS will have greater improvement of their memory disorders than those treated by sham CPAP.
Detailed description
We want to assess the evolution, before and 6 weeks after the beginning of the treatment, of the significant differences of the performances of the various memory tests evaluating several forms of memory (episodic memory, working memory, short-term memory and procedural memory) according to the treatment for patients with SAOS (effective versus sham).
Interventions
DEVICEEffective CPAP
Auto-titrating CPAP machines (Remstar Auto; Philips Respironics, Murrysville, PA) provided by a home care company (Bastide Medical, France). Pressure was set between 6 and 14 cm of water
DEVICESham CPAP
Similar CPAP machine delivering a 4 cm of water pressure that was too low to suppress sleep respiratory events.
Sponsors
University Hospital, Grenoble
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Major patients, * agreeing, * diagnosed suffering from the SAOS, * regulation by the specialist in a treatment by CPAP, * patients do not begin the treatment * affiliated to the social security, * fluent in French.
Exclusion criteria
* Patients presenting severe depressive disorders (HADS score\>19), * intellectual deterioration (MMS\< 28), * a functional failure of the dominant arm upper limb inhibiting realization of graphic tasks, * an associated oxygen treatment, * suffering from cancer, * cerebro-vascular accident, * pregnant or nursing women, * adult under supervision or trusteeship, * patients already included in another research protocol or in period of exclusion, * antidepressant and anxiolytic treatment.
Countries
France
Outcome results
None listed