Investigation of Correlation Between Interstitial and Arterial Blood Glucose Concentrations in Septic Patients

An Open, Mono-Centre Trial to Investigate the Correlation Between the Interstitial and Arterial Blood Concentrations of Glucose During Subcutaneous Glucose Monitoring in Patients With Severe Sepsis at the Medical Intensive Care Unit

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00463645

Enrollment

Registered

2007-04-20

Start date

2005-09-30

Completion date

2006-01-31

Last updated

2007-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Sepsis

Brief summary

This is a mono-centre trial performed at the medical ICU at the Medical University Graz. There will be a study visit (V1) and a follow-up assessment (V2). In the study visit (V1) arterial blood glucose values will be monitored and subcutaneous sampling of interstitial fluid (ISF) with microdialysis for glucose determination and with microperfusion for cytokine-measurement will be performed. The study visit will last for 26 hours starting with the insertion of two catheters in the abdominal subcutaneous tissue (one microdialysis- and one microperfusion catheter). The primary hypothesis of the study is: Interstitial fluid glucose concentration profiles correlates to the arterial blood glucose concentration profile in patients with severe sepsis in the medical ICU.

Interventions

PROCEDUREmicrodialysis

PROCEDUREmicroperfusion

Study design

Observational model

DEFINED_POPULATION

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patients in the medical ICU fulfilling criteria for severe sepsis * Mechanical ventilation * Increased blood glucose levels ( \> 120 mg/dL; \> 6.7 mM), or requiring insulin treatment. * Age of patients in the range from 18 to 90 years.

Exclusion criteria

* Any disease or condition which the Investigator or the treating physician feels would interfere with the trial or the safety of the patient

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026