Infertility, IVF Treatment
Conditions
Keywords
IVF, GnRH antagonist
Brief summary
Our goal was to investigate whether early follicular supplementation of the GnRH antagonist to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical results
Detailed description
GnRH antagonist offers many advantages when used in IVF-ET treatment, however, it is suspected to yield lower pregnancy rate when compared with the long GnRH agonist protocol. Our goal was to investigate whether early follicular supplementation of the GnRH antagonist to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical results. Consecutive patients are prospectively enrolled and randomly assigned to the study and control groups. Patients with low ovarian reserve or with uterine distortion are excluded from the study. Both groups are treated with recombinant FSH and the flexible GnRH antagonist protocol. Women in the study group are also treated with additional GnRH antagonist 0.25 mg/day on day 1, 2 and 3 of the menstrual cycle.
Interventions
DRUGGanirelix
sc injection of Ganirelix 0.25 mg per day
Sponsors
Organon
The Baruch Padeh Medical Center, Poriya
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* infertility * IVF candidate * failure of previous IVF attempt
Exclusion criteria
* low ovarian reserve * untreated distortion of uterine cavity * medical contraindication for IVF treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rates | one cycle |
Secondary
| Measure | Time frame |
|---|---|
| differences in hormonal levels | one cycle |
| differences in the basic treatment doses | one cycle |
| oocyte counts | one cycle |
| fertilization rate | one cycle |
| cleavage rate | one cycle |
Countries
Israel
Outcome results
None listed