Effect of Heredity and Environment on Asthma Development and Severity in Puerto Rican Children

Genes, Home Allergens, and Asthma in Puerto Rican Children

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00461227

Enrollment

1127

Registered

2007-04-17

Start date

2006-08-31

Completion date

2010-06-30

Last updated

2012-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, Hypersensitivity

Keywords

Puerto Rican, Allergies

Brief summary

Asthma is a major public health problem among Puerto Ricans. Little is known, however, about the effect of heredity and environment on the development and severity of asthma in this population. This study will examine the relationship between asthma and certain genetic and environmental factors in Puerto Rican children.

Detailed description

Asthma is a chronic disease that causes constriction of the airways. People with asthma may experience wheezing, coughing, chest tightness, and trouble breathing. Although asthma is a major public health problem among Puerto Ricans, little research has been done to determine the influence of heredity and environment on the disease in this population. To learn more about these relationships, this study will examine the effects of certain genes and allergens on the development and severity of asthma in Puerto Rican children. This observational study will recruit both children with asthma and children without asthma. Participants will meet with study staff twice during the study. The first visit will take place at participants' homes. Participants will complete questionnaires about demographics, respiratory and general health, and household characteristics. Lung function testing, collection of blood samples, and collection of household dust samples will also take place at the home-based visit. The second visit will take place at the study site. At this visit, participants will undergo allergy tests on the skin and a methacholine challenge test to assess their airway responsiveness and asthma severity. The methacholine challenge test will involve inhaling mist through a mouthpiece and blowing forcefully into a special apparatus called a spirometer. Parents will be asked to provide information about their children's exposure to pets in early life. Each visit will last approximately 1.5 hours and will be scheduled close to the date on which a participant enters the study.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

6 Years to 14 Years

Healthy volunteers

Inclusion criteria

For participants with asthma: * Diagnosis of asthma * History of wheezing within 12 months prior to study entry * Has four grandparents that were born in Puerto Rico For participants without asthma: * No diagnosis of asthma * No history of wheezing within 12 months prior to study entry * Has four grandparents that were born in Puerto Rico

Exclusion criteria

* Significant pulmonary disease other than asthma * Hospitalization in the neonatal intensive care unit and requiring ventilatory support * History of cigarette smoking for more than 5 pack-years (\[number of packs smoked per day\] x \[number of years of smoking\])

Design outcomes

Primary

Measure	Time frame
Effect of certain genes and allergens on the development and severity of asthma in Puerto Rican children	Measured at participants' two study visits

Countries

Puerto Rico

Outcome results