ADMA and Mechanical Ventilation in Preterm Infants

Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00460044

Enrollment

Registered

2007-04-13

Start date

2002-01-31

Completion date

2003-07-31

Last updated

2007-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature Birth

Keywords

ADMA, Preterms, infants, mechanical ventilation, Preterm infants

Brief summary

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

Detailed description

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

No minimum to 32 Weeks

Healthy volunteers

Inclusion criteria

* Gestational age \< 32 weeks * Birth weight \< 1500 gram * Written informed consent of parents

Exclusion criteria

* Congenital abnormalities * Chromosomal abnormalities

Outcome results