Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)

Randomized, Clinical Trial to Study the Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function, Oxidative Stress and Regenerative Capacity of Endothelial Progenitor Cells in Patients With Coronary Artery Disease

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00457379

Acronym

HERCET

Enrollment

Registered

2007-04-06

Start date

2007-04-30

Completion date

2008-04-30

Last updated

2007-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Coronary artery disease, HDL-Cholesterol, Endothelial Function, Endothelial Progenitor Cells, normal blood HDL-Cholesterol level

Brief summary

Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective properties. The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.

Interventions

BEHAVIORALphysical exercise

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Coronary artery disease * Normal HDL-cholesterol levels in blood: * \> 40 mg/dl (1.03 mmol/L) in males * \> 50 mg/dl (1.29 mmol/L) in females

Exclusion criteria

* Type 1 or 2 diabetes mellitus * Acute coronary syndrome * Unstable angina pectoris * Myocardial infarction during the last 8 weeks * Therapy with niacin * Active infections * Ventricular arrhythmias * Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 95 mmHg * Cancer * Pregnant or lactating * Alcoholism

Design outcomes

Primary

Measure	Time frame
vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training	—

Secondary

Measure	Time frame
flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound	—

Countries

Germany

Contacts

Primary ContactUlf Landmesser, MD

Landmesser.Ulf@MH-Hannover.de+49511532

Backup ContactKristina Sonnenschein

Sonnenschein.Kristina@MH-Hannover.de+49511532

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026