Hyperlipidemia, Postmenopausal
Conditions
Keywords
paraoxonase1 activity, LDL, HDL, postmenopausal women, postmenopausal women and hyperlipidemia
Brief summary
paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity
Detailed description
In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.
Interventions
PROCEDUREsoy consumption
Sponsors
Iran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
FEMALE
Age
51 Years to 57 Years
Healthy volunteers
Yes
Inclusion criteria
* Cessation of menes for more than 1 year, elevation for more than 1 year * Elevation of FSH level * Total cholesterol * Triglyceride more than 200 mg/dl
Exclusion criteria
* Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease) * Antihypertensive drugs * Antibiotics * Lipid lowering drugs * Sex hormone treatment * Hysterectomy * Diet rich in soy protein
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| decrease of LDL,increase of HDL,increase of paraoxonase 1 | — |
Outcome results
None listed