Schizophrenia
Conditions
Keywords
Seligiline, Negative symptoms, Schizopherenia
Brief summary
Antipsychotic drugs are effective in treating the positive symptoms of schizophrenia; however their efficacy in treating negative symptoms is limited. This study wants to evaluate efficacy of selegiline augmentation of antipsychotic medication to treat negative symptoms in inpatients with chronic schizophrenia. With randomized clinical trial two groups of patients will select to receive selegiline or placebo. Primary end point is decreasing in negative symptoms in case group. Inclusion criteria : 1- Patients with moderate to severe negative symptoms 2- Patients with at least one year antipsychotic drug therapy, at the current dose \>= 1 month. 3- No other psychotropic drugs during past month. Exclusion criteria: 1- Severe major depressive disorder, substance abuse, severe positive symptoms of schizophrenia, Treatment of MDD with antidepressant drugs during past month.
Interventions
DRUGSelegiline
Sponsors
Tabriz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients with moderate to severe negative symptoms * Patients with at least one year antipsychotic drug therapy, at the current dose \>= 1 month. * No other psychotropic drugs during past month
Exclusion criteria
* Severe major depressive disorder * Substance abuse * Severe positive symptoms of schizophrenia * Treatment of MDD with antidepressant drugs during past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| decreasing in negative symptoms in case group | — |
Countries
Iran
Outcome results
None listed