Coronary Atherosclerosis, HIV Infections
Conditions
Keywords
HIV, atherosclerosis
Brief summary
We will obtain data using multi-slice CT technology to detect subclinical coronary disease in the HIV population. Determination of subclinical cardiovascular disease using noninvasive technology and elucidation of the associated risk factors will help to guide targeted therapy to prevent cardiovascular events in this patient population. We will investigate the prevalence of coronary plaque lesions and coronary artery calcifications in men and women with HIV disease as determined by 64-row multidetector computed tomography (MDCT) and MDCT coronary angiography in comparison to age-matched control subjects without HIV infection. We hypothesize that evidence of coronary artery calcification and coronary plaque lesions as seen by MDCT will be present in individuals with HIV more than non-HIV control subjects of the same age. We also hypothesize the degree of atherosclerosis will be increased in HIV patients compared to control subjects. We will evaluate the metabolic and inflammatory factors associated with coronary artery disease in HIV-infected individuals. We hypothesize that traditional cardiac risk factors as well as metabolic and inflammatory changes associated with HIV and its treatment such as dyslipidemia, increased secretion of inflammatory markers, decreased adiponectin, increased insulin resistance and increased visceral fat may be associated with coronary artery disease in HIV-infected individuals.
Interventions
None listed
Sponsors
Bristol-Myers Squibb
Massachusetts General Hospital
Study design
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
for HIV infected subjects arm: 1. Men and women age 18-60 2. BMI 20-35 3. Previously documented HIV disease for 5 years or longer either on stable highly active anti-retroviral therapy (HAART) or not on HAART. 4. No changes in antiretroviral regimen within the prior 3 months. Inclusion criteria for non-HIV infected control subjects arm: 1. Healthy men and women age 18-60 2. BMI 20-35
Exclusion criteria
for both arms: 1. Previously diagnosed coronary artery disease, cerebrovascular disease, or peripheral vascular disease. 2. Use of glucocorticoids, growth hormone, testosterone, or other anabolic agents within past 6 months 3. Renal disease or creatinine \>1.5 mg/dL 4. Anti-inflammatory medications 5. Opportunistic infection within past 6 months in HIV infected individuals and current acute infectious illness in both HIV-infected subjects and normal controls. 6. Nitrates or others medications that can alter endothelial function 7. Contraindication to beta-blocker use 8. Body weight greater than 300 lbs due to DEXA scanner table limitations 9. Patients with previous allergic reactions to iodine-containing contrast media or to iodine will be excluded from participation 10. Active illicit drug use 11. Pregnancy or breastfeeding 12. Estrogen or progestin use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary Plaque | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory indices, glucose homeostasis, body composition | Baseline |
Countries
United States
Outcome results
None listed