Lung Function and Airway Inflammation in Portland Cement Workers

Airway Inflammation in Cement Dust Exposed Workers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00455377

Acronym

SPUTUM

Enrollment

Registered

2007-04-03

Start date

2007-03-31

Completion date

2008-12-31

Last updated

2013-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway Inflammation, Cement Dust Exposure, Peripheral Blood Inflammation Markers

Keywords

Cement dust exposure, Induced sputum, Airway inflammation, Peripheral blood inflammation markers

Brief summary

The aim of the study is to examine inflammation in the airways and in peripheral blood, in workers in a cement plant i Norway.

Detailed description

OBJECTIVE: Former studies have presented conflicting data on the association between exposure to Portland cement dust and respiratory effects. Our goal is to examine inflammation in the airways and in peripheral blood in subjects exposed to cement-dust. METHODS: All non smoking, dust exposed, workers from one department in the largest cement plant in Norway, are invited to participate. The workers will perform spirometry and induced sputum (IS) after a period of regular work with cement dust exposure, and again after a minimum of 5 days without exposure. Information on respiratory symptoms, allergy and former respiratory disease will be given on a self-reported questionnaire. IS was performed and processed as described by Pin et al. Differential cell counts will be carried out. Inflammatory markers in induced sputum and in peripheral blood will be measured. We want to use a crossover design were the cases are used as their own controls, but we will also include external controls.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 67 Years

Healthy volunteers

Yes

Inclusion criteria

* Cement dust exposure * Non-smoker or ex-smoker \>3 years

Exclusion criteria

* Infectious disease during the last 3 weeks * Chronic airway disease

Design outcomes

Primary

Measure	Time frame	Description
Percentage of neutrophile cells in induced sputum	Before and after a period of exposure	A significantly higher percentage of neutrophils was observed in induced sputum samples from cement production workers collected during an exposed period compared with a nonexposed period and compared with external controls.
Concentration of Interleukin 1beta in induced sputum	Before and after a period of exposure to cement production dust	The concentration of Interleukin 1beta was higher in the sputum of workers during an exposed period than that of the office workers or the external controls.

Countries

Norway

Outcome results