Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00453752

Enrollment

100

Registered

2007-03-29

Start date

2006-04-30

Completion date

2010-04-30

Last updated

2007-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic Sclerosis

Keywords

systemic sclerosis, pulmonary hypertension, echocardiography, N-Terminal proBNP

Brief summary

The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Detailed description

Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of systemic sclerosis

Exclusion criteria

* Cardiovascular disorders other than pulmonary hypertension * Significant pulmonary function abnormalities * Impaired renal function

Countries

Poland

Contacts

Primary ContactCiurzyński Michał, M.D, Ph.D

mciurzyn@amwaw.edu.pl+48 22 502 11 44

Backup ContactPiotr Pruszczyk, M.D, Ph.D.

ppruszczyk@amwaw.edu.pl+48 22 501 11 44

Outcome results