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Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation

Evaluation of BNP in Patients With Severe Acute Respiratory Failure Requiring Non Invasive Mechanical Ventilation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00453726
Enrollment
40
Registered
2007-03-29
Start date
2006-05-31
Completion date
2009-07-31
Last updated
2009-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Insufficiency

Keywords

Natriuretic peptide brain, Continuous positive airway pressure, Intermittent positive pressure breathing, Respiratory insufficiency

Brief summary

The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.

Detailed description

The aim of the study is to evaluate in patients with severe acute respiratory failure requiring non invasive mechanical ventilation BNP levels at admission and during the following 24 hours during non invasive mechanical ventilation (Non Invasive Positive Pressure Ventilation or Continuous positive airway pressure). Because in patients affected by acute respiratory failure it is often difficult to distinguish if the disease precipitating the respiratory failure is a cardiac disease or a lung disease, aim of the present study is to evaluate the discriminating role that BNP could have in this group of patients; evaluation will be completed, once obtained clinical stabilisation, with an echocardiography and respiratory functional test.

Interventions

Sponsors

Ospedale S. Giovanni Bosco
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* Severe respiratory distress (use of respiratory accessory muscles); * Respiratory rate \> 25 per minute; * Respiratory acidosis (pH \< 7.35 and PaCO2 \> 45 mmHg); * PaO2/FiO2 \< 250

Exclusion criteria

* Age \< 18 years; * Facial deformities; * Pneumothorax; * Shock or systolic arterial pressure below 90 mmHg with amine infusion; * Life-threatening arrhythmias; * Need for immediate endotracheal intubation (PaO2/FiO2 \< 100 with FiO2 100%, respiratory rate \< 10, GCS \< 8); * Lack of co-operation from the patient; * Recent esophageal-gastric surgery; * Inability to clear secretions; * Drugs that may interfere with BNP secretion; * Severe obesity; * Hepatic cirrhosis with ascitis; * Endocrine disease.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026