Sepsis
Conditions
Brief summary
The purpose of this study is to determine whether atorvastatin can improve the inflammatory answer in the septic patients
Interventions
DRUGamido pill
one pill of amido/d by mouth for 10 days
DRUGatorvastatina
atorvastatina 80 mg/day by mouth for 10 days
Sponsors
Hospital de Clinicas de Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* clinical diagnosis of several sepsis or shock septic * no more than twenty four hours than diagnosis
Exclusion criteria
* use of statins in the last thirty days * unequivocal indication for statin treatment * active treatment with imunosuppressors drugs * High risk of rhabdomyolysis: multiple trauma, crush injuries, baseline creatinine kinase \> three times upper limit of normal * diagnosis of AIDS * unable to receive enteral medications * pregnancy * expected survival of less than 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| action in inflammmatory biologic makers | 24h; 72h; 10 days |
| valuation of flow-mediated vasodilation of the brachial artery | 24h; 72; 10 days |
Secondary
| Measure | Time frame |
|---|---|
| mortality | at end |
| time of permanence in intensive care unity | at end |
| time of permanence in mechanical ventilation | at end |
Countries
Brazil
Contacts
Primary ContactKaren F Prado, investigator
Outcome results
None listed