Glaucoma, Pulmonary Hypertension
Conditions
Brief summary
There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve. Pulmonary hypertension (PH)is a disease characterized by low oxygen levels in the blood and altered blood circulation. The decrease in oxygen delivery to the optic nerve could lead to the loss of nerve fiber layer(NFL)in the retina and the resulting visual field compromise. This situation is characteristic of glaucoma. The ability to identify NFL thinning early could lead to earlier diagnosis of glaucoma and more effective treatment to limit dysfunction from visual field loss. We hypothesize that the rate of structural damage to the NFL, a feature of glaucoma, is higher in patients with PH than expected in healthy populations lacking this disease.
Interventions
None listed
Sponsors
University of Colorado, Denver
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* diagnosed with pulmonary hypertension * between the ages of 18 and 80 years * ability to undergo the various ocular exams.
Exclusion criteria
* patients with other diseases that could affect the nerve fiber layer * special populations; ie children, pregnancy, lactating females, prisoners
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurence of nerve fiber layer abnormalities | Single Exam |
Secondary
| Measure | Time frame |
|---|---|
| Optic Nerve Head Structure | Single Exam |
Other
| Measure | Time frame |
|---|---|
| Visual Field Defects | Single Exam |
| Retinal Blood Flow Changes | Single Exam |
Countries
United States
Outcome results
None listed