Graft Versus Host Disease
Conditions
Keywords
Graft versus host disease, Allogeneic hematpoietic stem cell transplantation
Brief summary
We plan to investigate prospectively and simultaneously skin and blood DC subtypes, their donor/recipient origin and the correlation of DC reconstitution kinetics with treatment, clinical outcome and incidence of aGvHD in patients undergoing allogeneic hematopoietic stem cell transplantation.
Detailed description
Blood and skin DC reconstitution shall be investigated in patients affected by hematological diseases and receiving HLA-matched, mobilized peripheral blood stem cells from related or unrelated donors. We plan to simultaneously collect and process double biopsies, i.e. from graft versus host disease affected and non-lesional skin of patients at onset of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Emigration assay, Chimerism analysis and immunohistochemistry will be performed.
Interventions
PROCEDUREblood draw, skin shave biopsy
Sponsors
Technische Universität Dresden
Study design
Observational model
DEFINED_POPULATION
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient undergoing an allogeneic hematopoietic stem cell transplantation * Older than 18 years * WHO-Performance-Status 0 to3 * Informed consent * Graft versus host disease of the skin
Exclusion criteria
* Clotting parameters more than double of normal * Infection of the skin * Leucocytes \< 1000/µl; Thrombocytes \< 20 000/µl
Countries
Germany
Contacts
Primary ContactSusanne Gretzinger, MD
Backup ContactMartin Bornhäuser, Professor
Outcome results
None listed