Glaucoma, Trabeculectomy
Conditions
Keywords
Glaucoma, Drug Resistance, Multiple, Trabeculectomy
Brief summary
We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.
Detailed description
Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.
Interventions
None listed
Sponsors
University of Cologne
Study design
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
8 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* patients with planned trabeculectomy for elevated eye pressure * one third of patients without previous trabeculectomy * two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)
Exclusion criteria
* patients not requiring surgery * patients with planned surgery for elevated eye pressure other than trabeculectomy
Countries
Germany
Outcome results
None listed