Autism
Conditions
Keywords
Magnetic Resonance Imaging, Diffusion Tensor Imaging
Brief summary
The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.
Interventions
None listed
Sponsors
UMC Utrecht
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
1. Aged 6 - 18 years at initial MRI Inclusion criteria for subjects with autism 1\) DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview Inclusion criteria for controls 1. no DSM-IV (APA, 1994) diagnosis, according to DISC interview 2. no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) 3. IQ \> 70
Exclusion criteria
1. major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system 2. presence of metal objects in or around the body (pacemaker, dental braces) 3. history of or present neurological disorder 4. for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
Countries
Netherlands
Contacts
Primary ContactSarah Durston
Outcome results
None listed