Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00449306

Enrollment

120

Registered

2007-03-20

Start date

2001-03-31

Completion date

2021-07-31

Last updated

2019-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Aneurysm, Atherosclerosis, Peripheral Vascular Diseases

Keywords

Atherosclerosis, Carotid plaque, Abdominal aortic aneurysm, Vulnerable plaque, Angiogenesis, Intraplaque hemorrhage, Carotid artery atherosclerosis

Brief summary

Lipid-rich atherosclerotic plaques, or vulnerable plaques are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives: 1 Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression. 2 Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques. 3 Explore the potential role of infection in atherogenesis.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Evidence of symptomatic carotid stenosis exceeding 60%(TIAs or stroke within the last 6 months), and asymptomatic carotid artery stenosis (presenting with progressive carotid stenosis, exceeding 70%) * Abdominal aortic aneurysm, and aortic occlusive disease * Peripheral occlusive or aneurysmal disease

Exclusion criteria

* Non-compliant patients, incapable of granting approval by informed consent

Design outcomes

Primary

Measure	Time frame
To uncover mechanisms of cardiovascular diseases	3 years

Countries

Israel

Outcome results