Bleeding
Conditions
Keywords
central venous catheter, international normalized ratio, thrombocytes, bleeding risk, all patients in need of central venous line, comparison of patients with normal hemostasis to such with disorders in hemostasis
Brief summary
Since many of the patients in an intensive care unit suffer from disorders of hemostasis, bleeding is a main concern applying central venous catheters. Even if there are some data indicating elevated international normalized ratio may not increase the risk of bleeding no clear cut-off has been defined so far. An INR \> 1.5 is generally considered to increase the risk of bleeding. Furthermore, many authors consider platelets below 50 x 109 /l as a contra-indication to CVC cannulation, since there are some data this may increase the risk of bleeding. Therefore platelet transfusion before venous puncture is suggested. In our clinical experience INR \> 1.5 and platelets \< 50 x 109 /l do not correlate with increased risk of bleeding. The aim of this study is to demonstrate, that coagulopathy, defined by INR and platelet count, is not decisive for bleeding.
Interventions
PROCEDUREcentral venous catheter application
Sponsors
Heidelberg University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients acquiring a central venous catheter
Exclusion criteria
* Patients pre or post surgery * Patients with bleeding due to other reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding within 24 hours after cvc application | — |
| other complications within the first 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| mortality | — |
| long-term complications | — |
Countries
Germany
Outcome results
None listed