Muscular Atrophy, Muscle Weakness
Conditions
Keywords
Muscle loss and Maintenance of Muscle function
Brief summary
The purpose of this study is to see if a combination of resistance exercises and amino acid capsules can reduce muscle loss and maintain muscle function during bedrest. This experiment will imitate many of the physical conditions experienced by astronauts during space flight by examining the effects of resistance exercise or nutrition on muscle during 2 days of bedrest. The diet of astronauts will also be imitated by providing diets in the General Clinic Research Center.
Interventions
BEHAVIORALResistance Exercise
Subjects will lift weights with their legs.
DIETARY_SUPPLEMENTdiet orange soda
Subjects drink diet orange soda 3x day for 2 days.
DIETARY_SUPPLEMENTessential amino acids
Subjects drink 15 grams of EAA mixed into diet orange soda 3x day for 2 days.
Sponsors
University of Arkansas
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-50 years of age * Availability of transport and ability to report to Research Center at appointed times
Exclusion criteria
* Subjects with limiting or unstable angina or a cardiology confirmed ECG which demonstrates cardiac abnormalities such as \> 0.2 mV horizontal or downsloping ST segment depression, frequent arrhythmia's (\>10 PVC/min), or valvular disease. * Subjects with vascular disease as determined by a combination of risk factors of peripheral atherosclerosis, namely hypertension, obesity, diabetes, hypercholesterolemia and/or evidence of venous or arterial insufficiency upon palpitation of femoral, popliteal, and pedal arteries. * Any history of hypo- or hyper-coagulation disorders including subjects taking Coumadin or with a history of DVT or PE at any point in their lifetime. * Any subject that has a chronically elevated systolic pressure \>170 or a diastolic blood pressure \> 100 will be excluded. Subjects may be included if they are taking blood pressure medication and have a blood pressure below these criteria. * Any subject with an uncontrolled metabolic disease including liver or renal disease. * Fasting blood glucose of \>126 mg/dl on two separate occasions * Presence of acute illness or metabolically unstable chronic illness. * Any subject currently on weight-loss diet. * Inability to abstain from smoking for duration of study. * Recent ingestion of anabolic steroids (within 6 months). * Subjects with atrial fibrillation, history of syncope, angina or congestive heart failure. * Subjects with a recently (6 months) treated cancer other than Basal Cell Carcinoma. * Pregnancy/lactation. * Any other condition or event considered exclusionary by the PI and covering faculty
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional synthetic rate of muscle growth. | two days. |
Countries
United States
Outcome results
None listed