Diabetes Mellitus
Conditions
Keywords
cataract surgery, endothelial cell, cell loss, diabetes, mellitus type II
Brief summary
The aim of the present study is to evaluate changes in the morphology and function of the corneal endothelium before and after cataract surgery in patients with diabetes type II. Also to explain if determination of HgbA1c in diabetics is a predictor for the changes in morphology and function.
Detailed description
Thirty patients with Diabetes type II and thirty non-diabetes patients scheduled to cataract surgery (phacoemulsification with intraocular lens implantation) were invited to participate in the study. Preoperatively, all patients had a full eye examination and 3 endothelial cell photos were taken. Three months postoperatively the patients were called for a re-examination including 3 endothelial cell photos. The function of the cornea is dependent of the number and morphology of the endothelial cells, and even small traumas like cataract surgery may disrupt the cornea integrity leading to corneal haze and blur. Diabetics may be more vulnerable to corneal stress.
Interventions
PROCEDUREcataract surgery
Sponsors
Frederiksberg University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with cataract scheduled for surgery
Exclusion criteria
* Patients with corneal diseases, glaucoma or uveitis, previous intraocular surgery or eye traumas.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| corneal endothelial cell count (cells / mm2) | — |
| percentage of hexagonal cells | — |
| variation in cell size | — |
| central corneal thickness | — |
Secondary
| Measure | Time frame |
|---|---|
| visual acuity | — |
| intraocular pressure | — |
Countries
Denmark
Outcome results
None listed