Anaesthesia
Conditions
Keywords
anaesthesia, propofol, desflurane, dreaming, electroencephalography
Brief summary
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.
Detailed description
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.
Interventions
DRUGPropofol
target controlled infusion of propofol
DRUGdesflurane
Anaesthetic maintenance with desflurane
Sponsors
Melbourne Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Male and female patients * Age between 18 and 50 years * Presenting for elective surgery under general anaesthesia
Exclusion criteria
* Inadequate English language comprehension * Major drug abuse problem
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire | recovery room stay |
Countries
Australia, New Zealand
Outcome results
None listed