Symptomatic Efficacy of Diacerein in Knee Osteoarthritis

Efficacy Study of Diacerein in the Symptomatic Treatment of Knee Osteoarthritis

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00445276

Enrollment

500

Registered

2007-03-08

Start date

2005-11-30

Completion date

2006-09-30

Last updated

2010-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

Osteoarthritis, Knee, Diacerein, Painful osteoarthritis, Clinical trial

Brief summary

Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis. This study aims at confirming the efficacy of diacerhein in symptomatic knee osteoarthritis using known and validated criteria and according to the recommendations and guidelines for this kind of study.

Interventions

DRUGDiacerein

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Painful primary osteoarthritis (VAS ≥ 40 mm) * Radiologically proven (Kellgren & Lawrence grade I to III) * Requiring the prescription of a symptomatic treatment of pain

Exclusion criteria

* Severe associated diseases * Wash-out: AINS, Coxibs, Paracetamol, anti-osteoarthritic treatments, hyaluronic acid, knee tidal lavage * Other osteoarticular disease

Design outcomes

Primary

Measure	Time frame
VAS on pain movement, WOMAC A 1.1 section	—

Secondary

Measure	Time frame
WOMAC : total, pain, physical function	—
Paracetamol consumption	—
Global assessment of the patient	—
Responder patients with OMERACT-OARSI criteria	—
Tolerance	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026