Genetic Analysis of Thyrotoxic Periodic Paralysis

Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00443833

Enrollment

Registered

2007-03-06

Start date

2004-01-31

Completion date

2005-12-31

Last updated

2007-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyrotoxic Periodic Paralysis

Keywords

Thyrotoxicosis, genetic association study, periodic paralysis, whole genome scan

Brief summary

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Detailed description

This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

MALE

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

TPP * Hyperthyroid patients from any causes * Evidence of hypokalemia (k\<3.5 mg/dl)from intracellular shift (Urine K\<15 mg/dl, TTKG\<2) * Episodic paralysis

Exclusion criteria

* Hypokalemia from GI or renal loss

Outcome results