S(+)-Ibuprofen Effects on Asprin Treated Volunteers

Double Blind, Randomised, Parallel Group, Placebo Controlled Clinical Trial of S(+)-Ibuprofen Effects on TxB2 Concentrations and Platelet Aggregation in Aspirin-treated Healthy Adult Volunteers

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00442585

Enrollment

Registered

2007-03-02

Start date

2006-09-30

Completion date

2007-10-31

Last updated

2012-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug Interactions

Brief summary

The purpose of this clinical trial is to determine whether S(+)-ibuprofen affect the platelet inhibition under steady state acetylsalicylic acid conditions.

Interventions

DRUGS(+)-ibuprofen

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy caucasian volunteer * Must be able to swallow tablets

Exclusion criteria

* Underlying diseases * Ulcus pepticum in history * Abuse of alcoholic beverages (40g/d) * Hypersensitivity to investigational medicinal products

Design outcomes

Primary

Measure	Time frame
Percentage of inhibition of TxB2 after 1, 3, 7 and 10 days	—

Secondary

Measure	Time frame
percentage of subjects with >90% inhibition of TxB2, CEPI-CT and CADP-CT measured by PAF100,	—
prostacyclin metabolite	—

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026