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Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery

Feasibility of Corticosteroid in the Prevention of Atrial Fibrillation After Cardiac Surgery: A Prospective, Double-Blind Randomized Multicenter Trial

Status
Terminated
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00442494
Enrollment
1
Registered
2007-03-02
Start date
2012-10-31
Completion date
2012-10-31
Last updated
2012-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Keywords

Atrial fibrillation after cardiac surgery

Brief summary

Atrial fibrillation is the most common arrhythmia to occur after cardiac surgery. Inflammatory response may be one etiological factor. We hypothesized that intravenous corticosteroid administration after cardiac surgery prevents AF after cardiac surgery.

Interventions

Sponsors

Tampere University Hospital
CollaboratorOTHER
Oulu University Hospital
CollaboratorOTHER
Kuopio University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* Patients scheduled to undergo their first on-pump CABG, aortic valve replacement or combined aortic valve replacement and CABG were enrolled.

Exclusion criteria

* Previous episodes of AF or flutter * Uncontrolled diabetes mellitus * Systemic mycotic infection * Active tuberculosis * Cushing's syndrome * Psychotic mental disorder * Herpes Simplex keratitis * Serum creatinine exceeding 200 µg/ml * Patients were also excluded if they had a history of previous peptic ulcer or thrombophlebitis.

Design outcomes

Primary

MeasureTime frameDescription
Study couldn´t start due to investigatorStudy couldn´t start due to investigatorStudy couldn´t start due to investigator

Secondary

MeasureTime frameDescription
Study couldn´t start due to investigatorStudy couldn´t start due to investigatorStudy couldn´t start due to investigator

Other

MeasureTime frameDescription
Study couldn´t start due to investigatorStudy couldn´t start due to investigatorStudy couldn´t start due to investigator

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 7, 2026