Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure

Effects of Cortisol on Carbohydrate, Lipid, and Protein Metabolism; Studies of Acute Cortisol Withdrawal in Adrenocortical Failure.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00442390

Enrollment

Registered

2007-03-01

Start date

2002-01-31

Completion date

2003-01-31

Last updated

2007-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Addison Syndrome

Keywords

Cortisol, adrenal insufficiency, glucose metabolism, protein metabolism, lipid metabolism, insulin sensitivity.

Brief summary

Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.

Interventions

DRUGhydrocortisone substitution therapy versus withdrawal

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Female adrenal failure * Age 18-50 * Written informed content

Exclusion criteria

* Diabetes mellitus * Cancer * Thromboembolic events * Pregnancy and lactation * Heart disease

Design outcomes

Primary

Measure	Time frame
insulin sensitivity	—
local protein turnover	—
whole body protein turnover	—
glucose metabolism	—
serum metabolites	—
serum hormone levels	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026