Dry Eye Syndrome
Conditions
Brief summary
To compare the therapeutic effect between autologous serum and umbilical cord serum eyedrops in the treatment of severe dry eye syndrome.
Detailed description
Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjögren's syndrome and 58 eyes of 31 patients with non-Sjögren's syndrome) were treated with either 20% autologous serum (41 eyes of 21 patients) or umbilical cord serum eyedrops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytology were performed before and 1 month and 2 months after treatment.
Interventions
Sponsors
Chonnam National University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
20 Years to 61 Years
Inclusion criteria
* Patients with severe dry eye syndrome who were refractory to conventional treatments and had symptoms of dry eye for more than 3 months * Low tear film break-up time (BUT, \< 5 sec) * Low Schirmer test (5 mm) * Positive fluorescein or rose bengal vital staining (≥ 3)
Exclusion criteria
* Active ocular infection or inflammation not associated with dry eye * Contact lens wear * Ocular allergy * Ocular surgery within the recent 3 months * Lid or lash abnormalities * Pregnant or lactating women
Countries
South Korea
Outcome results
None listed