Malnutrition
Conditions
Keywords
Internal medicine patients
Brief summary
The aim of the present study is to take stronger action in solving the problems of malnutrition in the hospital setting and in the first two months after patient's discharge. The main objective is to evaluate the clinical benefit (eg. QoL, body composition and body function) of nutritional intervention (nutritional therapy) in a sample of patients at nutritional risk according to the NRS 2002.
Interventions
OTHERNutritional therapy
Nutritional therapy by dietician
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all patients coming on station
Exclusion criteria
* patients with a screening total score \<3 according to the NRS-2002 system * less than 18 years of age, expected hospital stay less than 4 days * expected survival less than 1 month * pregnant or lactating women * patients with psychiatric disorders * patients with cardiac failure as defined by the Goldmann classification class \>II (recent rest pain, unstable angina pectoris) * patients with respiratory failure (Peak Flow Rate: PEFR \<50%) * patients with hepatic dysfunction (Child \>A) * patients suffering from an intestinal obstruction or ileus * patients with renal failure (creatinine \>250 μmol/l) or receiving haemodialysis * patients that are already receiving, or are planned to receive parenteral nutrition * patients unable to understand the German language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of stay | after stay |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body weight (measured day 1-2, 8, 28 and 56) and body composition (BMI, MAC, TSF) (measured day 1-2 and 8) | during stay |
| Changes in muscle function (handgrip dynamometry) (measured day 1-2 and 8) | during stay |
| Rate of accurately defined complications (infectious and non-infectious) (Table 2). Infectious are defined according to the US Centre of Disease Control [115]. | during stay |
| Quality of life | 2 months after stay |
| Rate of re-hospitalization (within 8 weeks after randomisation) | after stay |
| Rate of mortality | during and after stay |
| Rate of accurately defined post-discharge complications (infectious and non-infectious) (Table 2) | after stay |
Countries
Switzerland
Outcome results
None listed