Acute Lymphoblastic Leukemia
Conditions
Keywords
ALL
Brief summary
The present study aims at verifying the state of the art in what this illness concerns and at organizing a centralized samples analysis.
Detailed description
The present trial is a prospective multicentric GIMEMA study, in which adult ALL patients are extensively analyzed at diagnosis by a multiparametric approach including CC and molecular analysis for the following gene rearrangements: BCR-ABL, MLL-AF4, E2A-PBX1, TEL-AML1, MLL, p15 and p16 deletion in order to give place to a carefully characterization of the genetic lesions occurring in adult ALL and to evaluate their prognostic significance in a large cohort of patients homogeneously treated. This study requires a central handling and analysis of bone marrow (BM) or peripheral blood samples at presentation.
Interventions
DRUGHigh-dose anthracycline
Sponsors
Gruppo Italiano Malattie EMatologiche dell'Adulto
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 16-60 * Diagnosed with previously untreated T-ALL and B-ALL
Exclusion criteria
* previously treated ALL patients * L3 B-ALL
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with complete response | — | Patients are followed-up for response till death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients that reach disease-free-survival | — | Patients are followed-up for response till death |
Outcome results
None listed