Methamphetamine Dependence
Conditions
Brief summary
The purpose of this study is to determine if there are significant cardiovascular or other interactions between sublingual lobeline and intravenous methamphetamine.
Interventions
DRUGLobeline
Sponsors
National Institute on Drug Abuse (NIDA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Be between the ages of 18 and 45 years of age * Be in general good health with a history of methamphetamine (MA) abuse (but not dependence) * If female and of child bearing potential, agrees to use birth control * Be able to understand and provide written informed consent * Have a body mass index between 18 and 30 * Have reported use of (MA) during the past three months without experiencing adverse consequence plus a life time MA or amphetamine use history of at least four occasions of use * Have a negative drug test (barbiturates, benzodiazepines, amphetamines, opiates, cocaine, cannabinoids, ethanol) at screening and at the time of admission
Exclusion criteria
* Please contact site for details
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular responses | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective effects | — |
Countries
United States
Outcome results
None listed