Vancomycin Resistant Enterococcus Intestinal Carriage
Conditions
Keywords
Vancomycin Resistant Enterococcus, probiotic
Brief summary
This study aims to reduce the duration of VRE intestinal carriage by the administration of Lactobacillus casei rhamnosus (strain Lcr 35 LC). Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic (10 9 lactobacillus bid) or to a 5 weeks regimen with placebo.A stool culture will be performed every week for 5 weeks (during the administration of treatment) then every two weeks until 3 consecutive negative stool culture for VRE.
Detailed description
This study aims to reduce the duration of VRE intestinal carriage by the administration of Lactobacillus casei rhamnosus (strain Lcr 35 LC). Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic (10 9 lactobacillus bid) or to a 5 weeks regimen with placebo.A stool culture will be performed every week for 5 weeks (during the administration of treatment) then every two weeks until 3 consecutive negative stool culture for VRE.
Interventions
DRUGLactobacillus casei rhamnosus (strain Lcr 35 LC)
Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic or to a 5 weeks regimen with placebo.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18; * Vancomycin Resistant Enterococcus intestinal carriage
Exclusion criteria
* Neutropenia \<1000 /mm3, * Immunosuppressive drugs, * Inhalation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of the duration of Vancomycin Resistant Enterococcus intestinal carriage. | — |
Countries
France
Contacts
Primary ContactOlivier LESENS
Outcome results
None listed