Alcoholism
Conditions
Keywords
alcoholism, apomorphine, iodobenzamide, imaging, spect, relapse
Brief summary
OH dependence is associated with DA receptor changes. Both, the apomorphine test and the D2Rec SPECt are usefull for monitoring DA receptor status. We aimed at studying whether DA receptor hypofunction, assessed by means of the apomorphine test and the D2Rec SPECT, is a marker of relapse in detoxified OH dependents patients.
Interventions
DRUGapomorphine
Apomorphine 0.05 mg/kg subcutaneously at hospital admission and at discharge. Abstinent participants at 3 months will receive a third dose.
DRUG[(123)I] iodobenzamide
\[(123)I\] iodobenzamide 185 MBq I.V., at discharge.
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* alcohol dependence * alcohol dependence length at least 8 years. * male * age 25 - 60 years
Exclusion criteria
* other drug dependence (except nicotine dependence) * another major axis I psychiatric diagnosis * comorbid neurological disorder * comorbid cardiovascular disorder * comorbid metabolic disorder * brain injury * apomorphine allergy * iode allergy * diazepam allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To detertmine the agreement rate of the dopaminergic sensibility assessed by two different techiniques: the apomorphine test and and IBZM SPECT. | 3 months |
Countries
Spain
Contacts
Primary ContactMiquel Casas, Prof.
Backup ContactXavier Castells, Prof
Outcome results
None listed