Neuroaxial Blokade and Blood Pressure

Neuroaxial Blokade and the Effect of Fluid Optimization

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00435422

Enrollment

Registered

2007-02-15

Start date

2010-01-31

Completion date

2010-05-31

Last updated

2010-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypovolemia

Brief summary

The effect of individualized fluid optimization during neuroaxial blockade has not been evaluated. The investigators evaluated if if Stroke decrease 15 min after activation of neuroaxial blockade and whether SV could be optimized to pre activation values.

Detailed description

The purpose of this study is to evaluate SV maximization with aid of the LiDCO system which is a minimal invasive technique only requiring a venous and arterial line. We thereby attempt to cover the specific individual fluid deficit induced by neuroaxial blockade.

Interventions

PROCEDUREStroke volume optimization

Stroke volume optimization

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Neuroaxial blockade (thoracic)

Exclusion criteria

* Weight below 40 kg * Lithium therapy * Type I diabetes or type II requiring insulin

Design outcomes

Primary

Measure	Time frame
Stroke volume	15 min after blockade

Secondary

Measure	Time frame
Brain oxygenation, cardiac output, TPR, NIRS, BP	15 min after blockade

Countries

Denmark

Contacts

Primary ContactMorten Bundgaard-Nielsen, MD

morten.bundgaard-nielsen@rh.dk0045 35 45 09 55

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026